Lars-Erik Tammelin (16 March 1923 – 3 January 1991) was a Swedish

chemist A chemist (from Greek ''chēm(ía)'' alchemy; replacing ''chymist'' from Medieval Latin ''alchemist'') is a scientist trained in the study of chemistry. Chemists study the composition of matter and its properties. Chemists carefully describe th ...

, defence researcher and civil servant. Tammelin served as Director-General of the

Swedish National Defence Research Institute Swedish National Defence Research Institute ( sv, Försvarets forskningsanstalt, FOA) was a Swedish government agency in defense research existing from 1945 to 31 December 2000. It was amalgamated with the National Aeronautical Research Institute ...

from 1984 to 1985.

Career

Tammelin was born in

Stockholm Stockholm () is the Capital city, capital and List of urban areas in Sweden by population, largest city of Sweden as well as the List of urban areas in the Nordic countries, largest urban area in Scandinavia. Approximately 980,000 people liv ...

, Sweden, the son of Supreme Court Justice Erik Tammelin and his wife Elsa (née Palm). Tammelin, who was an

organic chemist Organic chemistry is a subdiscipline within chemistry involving the scientific study of the structure, properties, and reactions of organic compounds and organic materials, i.e., matter in its various forms that contain carbon atoms.Clayden, J.; ...

, was recruited to the

(FOA) in 1950 for research on

nerve gas Nerve agents, sometimes also called nerve gases, are a class of organic chemicals that disrupt the mechanisms by which nerves transfer messages to organs. The disruption is caused by the blocking of acetylcholinesterase (AChE), an enzyme that ...

and nerve gas

countermeasure A countermeasure is a measure or action taken to counter or offset another one. As a general concept, it implies precision and is any technological or tactical solution or system designed to prevent an undesirable outcome in the process. The fi ...

s. At this time, FOA (whose previous

chemical warfare Chemical warfare (CW) involves using the toxic properties of chemical substances as weapons. This type of warfare is distinct from nuclear warfare, biological warfare and radiological warfare, which together make up CBRN, the military acronym ...

activities had focussed on

mustard gas Mustard gas or sulfur mustard is a chemical compound belonging to a family of cytotoxic and blister agents known as mustard agents. The name ''mustard gas'' is technically incorrect: the substance, when dispersed, is often not actually a gas, b ...

and other

World War I World War I (28 July 1914 11 November 1918), often abbreviated as WWI, was one of the deadliest global conflicts in history. Belligerents included much of Europe, the Russian Empire, the United States, and the Ottoman Empire, with fightin ...

-style compounds) had become aware that large quantities of nerve gas, primarily Tabun, had been stockpiled during World War II. The mechanism of action of the nerve gases were found to be linked to their chemical similarity to the

neurotransmitter A neurotransmitter is a signaling molecule secreted by a neuron to affect another cell across a synapse. The cell receiving the signal, any main body part or target cell, may be another neuron, but could also be a gland or muscle cell. Neuro ...

acetylcholine Acetylcholine (ACh) is an organic chemical that functions in the brain and body of many types of animals (including humans) as a neurotransmitter. Its name is derived from its chemical structure: it is an ester of acetic acid and choline. Part ...

and their ability to block the

enzyme Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products. A ...

cholinesterase The enzyme cholinesterase (EC 3.1.1.8, choline esterase; systematic name acylcholine acylhydrolase) catalyses the hydrolysis of choline-based esters: : an acylcholine + H2O = choline + a carboxylate Several of these serve as neurotransmitters ...

. Much of Tammelin's work was therefore focussed on choline

ester In chemistry, an ester is a compound derived from an oxoacid (organic or inorganic) in which at least one hydroxyl group () is replaced by an alkoxy group (), as in the substitution reaction of a carboxylic acid and an alcohol. Glycerides ar ...

s. In 1958, he defended a

Ph.D. A Doctor of Philosophy (PhD, Ph.D., or DPhil; Latin: or ') is the most common degree at the highest academic level awarded following a course of study. PhDs are awarded for programs across the whole breadth of academic fields. Because it is a ...

thesis based on this work at

Stockholm University College Stockholm University ( sv, Stockholms universitet) is a public research university in Stockholm, Sweden, founded as a college in 1878, with university status since 1960. With over 33,000 students at four different faculties: law, humanities, soci ...

. The same year he became

Docent The title of docent is conferred by some European universities to denote a specific academic appointment within a set structure of academic ranks at or below the full professor rank, similar to a British readership, a French " ''maître de conf ...

in organic chemistry at Stockholm University College. The esters that form analogues to the V-Series of nerve agents are sometimes referred to as "Tammelin's esters".

Succinylcholine Suxamethonium chloride, also known as suxamethonium or succinylcholine, or simply sux by medical abbreviation, is a medication used to cause short-term paralysis as part of general anesthesia. This is done to help with tracheal intubation or ele ...

, one of the compounds synthesized by Tammelin in his search for nerve gas countermeasures, was put into use as a

muscle relaxant A muscle relaxant is a drug that affects skeletal muscle function and decreases the muscle tone. It may be used to alleviate symptoms such as muscle spasms, pain, and hyperreflexia. The term "muscle relaxant" is used to refer to two major therapeu ...

for use during

general anaesthesia General anaesthesia (UK) or general anesthesia (US) is a medically induced loss of consciousness that renders the patient unarousable even with painful stimuli. This effect is achieved by administering either intravenous or inhalational general ...

surgery Surgery ''cheirourgikē'' (composed of χείρ, "hand", and ἔργον, "work"), via la, chirurgiae, meaning "hand work". is a medical specialty that uses operative manual and instrumental techniques on a person to investigate or treat a pat ...

under the brand name Celocurin. In 1961, Tammelin became head of the chemical-medical division at FOA, when he succeeded

Gustaf Ljunggren Gustaf Ljunggren may refer to: * Gustaf Ljunggren (academician) Gustaf Håkan Jordan Ljunggren (6 March 1823 – 13 August 1905), Swedish man of letters, was born at Lund, the son of a clergyman. He was educated at Lund University, where he w ...

. Tammelin became a medical honorary doctorate at

Karolinska Institutet The Karolinska Institute (KI; sv, Karolinska Institutet; sometimes known as the (Royal) Caroline Institute in English) is a research-led medical university in Solna within the Stockholm urban area of Sweden. The Karolinska Institute is consiste ...

in 1973. He was professor and research director of the National Food Administration from 1975 to 1982 and Director-General of FOA from 1984 to 1985.

Personal life

In 1946 he married Isa Nilson (born 1922), the daughter of factory manager Nils Konrad Nilson and Sigrid Johansson. Tammelin died on 3 January 1991 and was buried at Bromma Cemetery on 10 April 1991.

Honours

*Honorary Doctor of Medicine (1973)

Bibliography

* *

References

{{DEFAULTSORT:Tammelin, Lars-Erik 1923 births 1991 deaths Swedish chemists Stockholm University alumni Stockholm University faculty Scientists from Stockholm